Publications by authors named "M M Winkler"
Most bacteria lack membrane-enclosed organelles and rely on macromolecular scaffolds at different subcellular locations to recruit proteins for specific functions. Here, we demonstrate that the optogenetic CRY2-CIB1 system from Arabidopsis thaliana can be used to rapidly direct proteins to different subcellular locations with varying efficiencies in live Escherichia coli cells, including the nucleoid, the cell pole, the membrane, and the midcell division plane. Such light-induced re-localization can be used to rapidly inhibit cytokinesis in actively dividing E.
View Article and Find Full Text PDFis a common cause of pulmonary and invasive mold infections among immunocompromised hosts. Mortality in immunocompromised hosts with invasive infections (IAI) has been reported to be as high as 80%. Therefore, appropriate therapy is essential in treating IAI.
View Article and Find Full Text PDFShelters in Alpine Rescue: Can They Create a Comfortable Zone at the Deployment Site?
Wilderness Environ Med
December 2024
Article Synopsis
- Lightweight polyester shelters are commonly used in mountain rescue, but little is known about the stress experienced by rescuers while using them.
- A study with 48 seasoned rescuers assessed both objective (temperature, humidity, gas concentrations) and subjective stress factors (comfort, noise, air quality) during CPR training in these shelters.
- The findings indicate that the shelters significantly improved physical comfort and most rescuers reported positive working conditions despite rising temperatures and carbon dioxide levels during the process.
Decentralized consensus on the state of the Bitcoin blockchain is ensured by proof of work. It relies on digital one-way functions and is associated with an enormous environmental impact. This paper conceptualizes a physical one-way function that aims to transform a digital, electricity-consuming consensus mechanism into a physical process.
View Article and Find Full Text PDF