Amino acid distribution in brain after use of amphetamines and beta-phenylethylamine.

Amino acids in rat brain were assayed after IP injection d-amphetamine or beta-phenylethylamine (PEA). Results revealed elevated values when one utilized 2.0-12 mg/kg of d-amphetamine.

Influence of drugs on macromolecular synthesis during cell synchronization.

A cell culture system has been used to examine the effect of various pharmacologic agents on DNA synthesis with the hope of utilizing this system for the evaluation of drugs at the cellular level. Glucocorticoids have been shown to have a differential effect on growth dependent on the cell type studied. For this reason steroidal anti-inflammatory agents were chosen to study in our culture system.

Amphetamine stereotypies and polyribosomal disaggregation in rats: effects of adrenergic and serotonergic blocking agents.

To find the specific chemical moiety responsible for the disaggregation of polyribosomes after induction of aberrant behavior by d-amphetamine, specific amine blockers and reserpine were utilized. It appears that dopamine is responsible for both the disaggregation of polyribosomes and stereotypic behavior while the roles of serotonin and norepinephrine are not significant in this system.