Publications by authors named "M M Welling"
Article Synopsis
- The study focuses on using a recurrent neural network with complex numbers to perform image segmentation by analyzing spatiotemporal dynamics.
- The network can effectively group different parts of an image based on the scene's structural features, demonstrating its versatility across various image types.
- An exact mathematical solution of the network's dynamics is provided, clarifying how a single recurrent neural network with fixed weights can achieve object segmentation efficiently.
Article Synopsis
- - Structure-based drug design (SBDD) focuses on creating small molecules that accurately target specific proteins, using structural data to help propose new drug candidates.
- - Current methods typically require extensive dataset preparation and retraining for different tasks, while our approach introduces a single pretrained model that can handle multiple design challenges.
- - We introduce DiffSBDD, a diffusion model that generates new ligands based on protein structures, and demonstrate how it can be enhanced with constraints for better drug candidate quality.
The ability of bacteria to recycle exogenous amino acid-based peptides and amino sugars for peptidoglycan biosynthesis was extensively investigated using optical imaging. In particular, fluorescent AeK-NBD was effectively utilized to study the peptidoglycan recycling pathway in Gram-negative bacteria. Based on these promising results, we were inspired to develop the radioactive AeK conjugate [Ga]Ga-DOTA-AeK for the in vivo localization of bacterial infection using PET/CT.
View Article and Find Full Text PDFCannabis sativa L. is one of the oldest domesticated crops. Hemp-type cultivars, which predominantly produce non-intoxicating cannabidiol (CBD), have been selected for their fast growth, seed, and fibre production, while drug-type chemovars were bred for high accumulation of tetrahydrocannabinol (THC).
View Article and Find Full Text PDFObjective: The increasing resistance of yeasts against commonly used antifungal drugs dictates the need for novel antifungal compounds. Human lactoferrin-based peptides show a broad spectrum of antimicrobial activities. Various assays were performed to find the optimal growth conditions of the yeasts and to assess cell viability, using media with low lipid content to avoid peptide binding to medium components.
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