Publications by authors named "M M WINBURY"

Clonidine-induced coronary vasodilation was studied in anesthetized dogs pretreated with propranolol to achieve beta-adrenoceptor blockade. The left circumflex coronary artery (LCX) was perfused with arterial blood from a reservoir maintained under a constant pressure of 100 mm Hg. Clonidine when administered directly into the coronary vascular bed in doses of 30, 100, and 300 micrograms induced a dose dependent coronary vasodilation, which was inhibited by cimetidine, but not by idazoxan, methysergide, methylscopolamine, yohimbine, diphenhydramine, ketanserin, or theophylline.

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1. The effect of intravenous pentaerythritol trinitrate and glyceryl trinitrate on left ventricular subepicardial (epi) and subendocardial (endo) PO2 and perfusion were compared in anaesthetized open-chest mongrel dogs. Tissue PO2 was determined simultaneously at a depth of 3 mm (epicardial) and 9 mm (endocardial) with small platinum electrodes by polarography.

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1. The effects of pentaerythritol trinitrate (pentrinitrol) and glyceryl trinitrate on myocardial oxygen consumption and myocardial and systemic haemodynamics were studied in anaesthetized open-chest dogs. An in vivo oximeter in the coronary sinus permitted continuous determination of arteriovenous oxygen difference and myocardial oxygen consumption.

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