Genetic variations underlying aminoglycoside resistance in antibiotic-induced Mycobacterium intracellulare mutants.

Mycobacterium avium complex (MAC) is an emerging pathogen leading to public health concerns in developing and developed countries, particularly among immunocompromised individuals and patients with structural lung diseases. Current clinical guidelines recommend combination antibiotic therapy for treating MAC pulmonary disease (MAC-PD). However, the rising prevalence of antibiotic resistance poses significant challenges, including treatment failure and clinical recurrence.

GLAC-Unet: Global-Local Active Contour Loss with an Efficient U-Shaped Architecture for Multiclass Medical Image Segmentation.

The field of medical image segmentation powered by deep learning has recently received substantial attention, with a significant focus on developing novel architectures and designing effective loss functions. Traditional loss functions, such as Dice loss and Cross-Entropy loss, predominantly rely on global metrics to compare predictions with labels. However, these global measures often struggle to address challenges such as occlusion and nonuni-form intensity.

Predisposition footprints in the somatic genome of Wilms tumours.

Ten percent of children with cancer harbour a mutation in a predisposition gene. In children with the kidney cancer, Wilms tumour, the prevalence is as high as 30%. Certain predispositions are associated with defined histological and clinical features, suggesting differences in tumourigenesis.