Publications by authors named "M M Tomasiak-Lozowska"
Article Synopsis
- Activated neutrophils produce myeloperoxidase (MPO), which generates hypochlorous acid (HOCl) that can disrupt blood clotting by inhibiting platelet aggregation and increasing fibrin density.
- The study examined the effects of three antioxidant plant-derived polyphenols: quercetin (Que), epigallocatechin gallate (EGCG), and resveratrol (Resv) on the hemostatic disturbances caused by HOCl.
- Que and EGCG were found to reverse the negative effects of HOCl on platelet aggregation and fibrin density, whereas Resv increased HOCl's inhibitory effects, suggesting that Que and EGCG could help normalize blood coagulation
Hypochlorite (HOCl), a strong oxidant and antimicrobial agent, has been proposed to be associated with hemostatic abnormalities during inflammatory response. However, its complex impact on hemostasis is not completely understood. In this report we studied the effect of clinically relevant (micromolar) HOCl concentrations on thrombus formation under flow, kinetics of platelet-fibrin clot formation, its architecture, retraction, and lysis.
View Article and Find Full Text PDFAnaphylaxis is defined as severe, life-threatening, systemic or general, immediate reaction of hypersensitivity, with repeatable symptoms caused by the dose of stimulus which is well tolerated by healthy persons. The proper diagnosis, immediate treatment and differential diagnosis are crucial for saving patient's life. However, anaphylaxis is relatively frequently misdiagnosed or confused with other clinical entities.
View Article and Find Full Text PDFThe aim of this study was to assess whether steroid-naïve asthma modulates hemostasis. We evaluated the clot retraction rate (CRR), fibrinolysis rate (FR), clot density (CD) (by confocal microscopy), plasma levels of plasminogen activator inhibitor (PAI-1), and factor XIII (FXIII), NO in exhaled breath (FE ), spirometry (FEV ) and eosinophil count (EOS) in 36 patients with allergic, steroid-naïve asthma and in 34 healthy controls. We observed significantly (P < 0.
View Article and Find Full Text PDFBackground: The involvement of B cells in allergen tolerance induction remains largely unexplored. This study investigates the role of B cells in this process, by comparing B-cell responses in allergic patients before and during allergen immunotherapy (AIT) and naturally exposed healthy beekeepers before and during the beekeeping season.
Methods: Circulating B cells were characterized by flow cytometry.