Publications by authors named "M M Sunil Paul"

Soil colour is a key indicator of soil health and the associated properties. In agriculture, soil colour provides farmers and advises with a visual guide to interpret soil functions and performance. Munsell colour charts have been used to determine soil colour for many years, but the process is fallible, as it depends on the user's perception.

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The translocation of proteins from the cytoplasm to the endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation of a CUP1 copper metallothionein and copper exposure inhibits the activity of Sec61. However, the role of epigenetic dysregulation on the activity of channel is not clear.

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Corticosteroid binding globulin (CBG; SERPINA6) binds >85% of circulating glucocorticoids but its influence on their metabolic actions is unproven. Targeted proteolytic cleavage of CBG by neutrophil elastase (NE; ELANE) significantly reduces CBG binding affinity, potentially increasing 'free' glucocorticoid levels at sites of inflammation. NE is inhibited by alpha-1-antitrypsin (AAT; SERPINA1).

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Article Synopsis
  • HFpEF makes up about 50% of heart failure cases globally, increasing due to longer lifespans and more health issues.
  • Wnt signaling is linked to heart problems like cardiomyocyte hypertrophy and fibrosis, and PORCN inhibitors (like Wnt-c59) show promise in improving heart function.
  • In a study, Wnt-c59 reduced adverse heart changes and improved heart function in mice with HFpEF, even though Wnt signaling itself wasn't activated in their hearts.
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