Publications by authors named "M M Steinhoff"
Article Synopsis
- The study examines the effects of Neosetophomone B (NSP-B), a fungal metabolite, on T-cell acute lymphoblastic leukaemia (T-ALL) cells, highlighting its anti-cancer properties.
- NSP-B was found to significantly inhibit T-ALL cell growth by causing cell cycle arrest and promoting apoptosis, while also deactivating the crucial PI3K/AKT/mTOR signalling pathway.
- Importantly, NSP-B showed selectivity by reducing proliferation in activated T cells without affecting normal T cells, indicating its potential as a targeted therapy for T-ALL.
Interleukin-31: The Inflammatory Cytokine Connecting Pruritus and Cancer.
Front Biosci (Landmark Ed)
August 2024
Article Synopsis
- Interleukin 31 (IL-31) is a cytokine produced mainly by Type II helper T cells, involved in inflammation and linked to causing itching (pruritus) in mammals.
- *High levels of IL-31 are associated with advanced cancers and increased severity of pruritus, impacting quality of life for cancer patients.
- *The exact role of IL-31 in various cancers is still unclear, but it may either promote or inhibit cancer progression, suggesting a complex relationship between cancer and pruritus.
Article Synopsis
- * The article highlights the significance of incorporating mind-body therapies (MBT) in treating AD, including techniques like meditation, cognitive behavioral therapy, and mindfulness.
- * Although research is limited, a holistic approach combining MBT and traditional treatments may enhance symptom management and psychological health, especially by breaking the itch-scratch cycle.
Article Synopsis
- The ALLEGRO study showed that ritlecitinib, a JAK3/TEC inhibitor, is effective and safe for treating alopecia areata in patients aged 12 and older with significant scalp hair loss.
- A post hoc analysis examined how previous alopecia treatments affected treatment outcomes using the Severity of Alopecia Tool (SALT) in patients taking ritlecitinib.
- Results indicated that prior use of intralesional corticosteroids improved short-term outcomes, while systemic immunosuppressants worsened them, but overall, previous treatment history did not significantly influence long-term responses to ritlecitinib.
Macrolide antibiotic azithromycin is widely used in clinical practice to treat respiratory tract infections and inflammatory diseases. However, its mechanism of action is not fully understood. Given the involvement of the CD27 pathway in the pathophysiology of various T-lymphocyte-mediated inflammatory, autoimmune, and lymphoproliferative diseases, we examined the impact of AZM on CD27 regulation and potential consequences on CD4+ and CD8+ T-cell phenotypes.
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