Publications by authors named "M M Steinhardt"
Advances in CD19-targeting CAR-T cell therapies for multiple myeloma.
Expert Opin Biol Ther
January 2025
Introduction: Emerging evidence suggests that, while CD19 is primarily expressed on immature B-cell precursors, it is also present on drug-resistant plasma cells that have been postulated to function as multiple myeloma (MM) stem cells, driving the progression of relapsing disease. Targeting CD19 with chimeric antigen receptor (CAR) T cells offers a promising strategy for addressing this residual disease burden, potentially leading to more durable treatments and enhanced relapse prevention.
Areas Covered: This review examines the molecular basis of CD19-targeted CAR-T therapy in MM, highlighting its potential, key challenges, and efficacy and safety in early clinical trials for relapsed/refractory and newly diagnosed MM.
Article Synopsis
- African American adults with Type 2 diabetes are increasingly affected by the disease, and the connection between their diet quality and glycemic control (measured by HbA1c levels) is not well understood.
- This study analyzed data from 273 African American adults with Type 2 diabetes, using dietary recalls and blood samples to assess the impact of processed versus unprocessed foods on blood sugar levels.
- Results showed that higher consumption of ultraprocessed foods was linked to higher HbA1c levels, while a diet rich in unprocessed or minimally processed foods was associated with better glycemic control.
Extramedullary disease (EMD) is a high-risk feature of multiple myeloma (MM) and remains a poor prognostic factor, even in the era of novel immunotherapies. Here, we applied spatial transcriptomics (RNA tomography for spatially resolved transcriptomics [tomo-seq] [n = 2] and 10x Visium [n = 12]) and single-cell RNA sequencing (n = 3) to a set of 14 EMD biopsies to dissect the 3-dimensional architecture of tumor cells and their microenvironment. Overall, infiltrating immune and stromal cells showed both intrapatient and interpatient variations, with no uniform distribution over the lesion.
View Article and Find Full Text PDFBackground: In light of increasing therapeutic options, risk stratification of advanced cardiac transthyretin amyloidosis (ATTR-CA) is gaining clinical importance to avoid ineffective treatments. Liver stiffness as a marker of hypervolemia and hepatic congestion might predict mortality in advanced ATTR-CA and allow to identify patients at highest risk.
Methods: Proven ATTR-CA patients underwent repeated vibration-controlled transient elastography (VTCE) and standardized serial workup within the local amyloidosis cohort study AmyKoS.