Publications by authors named "M M Shamsi"
Hypospadias, a common congenital anomaly of male genitalia, shows significant heritability and familial recurrence, particularly in consanguineous families. This study explored the role of KMT2C polymorphisms in a Yemeni family with two affected siblings. Comprehensive analysis identified 475 unique SNPs in KMT2C, with 59 shared between parents, suggesting common ancestry.
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- A Sn(IV) complex was synthesized using the ligands 2,2'-bipyridyl and indole-3-carboxylic acid, and thoroughly characterized with various analytical techniques such as elemental analysis, UV-vis, and NMR.
- Binding studies revealed that the Sn(IV) complex interacts strongly with the phosphate backbone of DNA and with the subdomain IIA of human serum albumin (HSA), indicating significant electrostatic interactions.
- The nature of the ligands attached to the Sn(IV) center influenced its binding properties, suggesting the complex has potential as an effective anticancer drug candidate.
Background: Different treatments have been proposed for patients with deep gluteal syndrome (DGS). Stretching and compression exercises are commonly used to treat DGS.
Objective: To compare the effects of compression or stretching exercises on the flexion-relaxation response (electromyography signals of back muscles) in patients with DGS.
Background: White matter hyperintensities (WMH) observed in T2 fluid-attenuated inversion recovery (FLAIR) images have emerged as potential markers of neurodegenerative diseases like Multiple Sclerosis (MS). Lacking comprehensive automated WMH classification systems in current research, there is a need to develop accurate detection and classification methods for WMH that will benefit the diagnosis and monitoring of brain diseases.
Objective: Juxtacortical WMH (JCWMH) is a less explored subtype of WMH, primarily due to the hard definition of the cortex in FLAIR images, which is escalated by the presence of lesions to obtain appropriate gray matter (GM) masks.