Publications by authors named "M M Sechi"
Parkinson's disease (PD) is a progressive age-related neurodegenerative disorder affecting millions of people worldwide. Essentially, it is characterised by selective degeneration of dopamine neurons of the nigro-striatal pathway and intraneuronal aggregation of misfolded α-synuclein with formation of Lewy bodies and Lewy neurites. Moreover, specific small molecules of intermediary metabolism may have a definite pathophysiological role in PD.
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- This study investigates the potential link between psoriasis, psoriatic arthritis, and the risk of peripheral neuropathy, aiming to understand its features in affected patients compared to a control group.
- Out of 200 participants, 9 with psoriasis or psoriatic arthritis were diagnosed with polyneuropathy, indicating a significant relative risk compared to the control group, who had none.
- Although there seems to be an association with increased risk of polyneuropathy in these patients, it is suggested that this risk is more due to other contributing health factors rather than the conditions themselves.
Neuroblastoma (NB) is the most commonly diagnosed extracranial solid tumor in children, accounting for 15% of all childhood cancer deaths. Although the 5-year survival rate of patients with a high-risk disease has increased in recent decades, NB remains a challenge in pediatric oncology, and the identification of novel potential therapeutic targets and agents is an urgent clinical need. The RNA-binding protein LIN28B has been identified as an oncogene in NB and is associated with a poor prognosis.
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- * Researchers analyzed 202 MG patients from 2010 to 2019, finding that the incidence was 32.6/million and prevalence was 55.3/100,000, with the majority testing positive for acetylcholine receptor antibodies.
- * The findings suggest that Sardinia has a higher prevalence of MG than the European average for rare diseases, highlighting the need to explore environmental and genetic factors contributing to this increased risk.
Natural α-glucosidase inhibitors from plant-based foods such as catechins offer an attractive strategy for their potential anti-diabetic effects. In this study, infusions of three different tea types (green, white, and oolong) were investigated for their total phenolic (TPC) and catechins (EGCG, ECG, EGC, and EC) content, and for their α-glucosidase inhibitory activities. We observed that the level of TPC in white tea was significantly higher compared to oolong and green tea, which suggests higher content of EGCG and ECG catechins in fresh young leaves.
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