Publications by authors named "M M Scully"
Demystifying autoimmune HIT: what it is, when to test, and how to treat.
Hematology Am Soc Hematol Educ Program
December 2024
Article Synopsis
- Antibodies to platelet factor 4 (PF4) are mainly associated with classical heparin-induced thrombocytopenia (cHIT), while a new condition called vaccine-induced thrombocytopenia and thrombosis (VITT) has emerged related to COVID-19 vaccines.
- Differentiation between heparin-dependent and heparin-independent anti-PF4 conditions has led to the development of a rapid anti-PF4 assay that is not affected by heparin.
- VITT-like disorders, which present independently of heparin and are often triggered by infections or certain surgeries, are rare but associated with high mortality and require specific treatment approaches like immunomodulation therapy.
Background: Depression alleviation following treatment with repetitive transcranial magnetic stimulation (rTMS) tends to be more effective when TMS is targeted to cortical areas with high (negative) resting state functional connectivity (rsFC) with the subgenual anterior cingulate cortex (sgACC). However, the relationship between sgACC-cortex rsFC and the TMS-evoked response in the sgACC is still being explored and has not yet been established in depressed patients.
Objectives: In this study, we investigated the relationship between sgACC-cortical (site of stimulation) rsFC and induced evoked responses in the sgACC in healthy controls and depressed patients.
Article Synopsis
- Researchers successfully resonantly excited a 1.4 feV ultranarrow nuclear transition in ^{45}Sc for the first time using the EuXFEL laser, marking a significant step towards a nuclear clock.
- The experiment demonstrated the high potential of x-ray free-electron lasers but also revealed limitations due to their large spectral bandwidth of approximately 1 eV.
- To overcome this, a method is proposed that uses a resonant absorber with a frequency gradient to enhance spectral flux, potentially achieving about a hundredfold increase in efficiency for nuclear excitation in ^{45}Sc_{2}O_{3} single crystals, crucial for future nuclear clock development.