Publications by authors named "M M Schindler"
Background And Purpose: The central vein sign (CVS) is a diagnostic imaging biomarker for multiple sclerosis (MS). FLAIR* is a combined MRI contrast that provides high conspicuity for CVS at 3 Tesla (3T), enabling its sensitive and accurate detection in clinical settings. This study evaluated whether CVS conspicuity of 3T FLAIR* is reliable across imaging sites and MRI vendors and whether gadolinium (Gd) contrast increases CVS conspicuity.
View Article and Find Full Text PDFAmong hornbill birds, the critically endangered helmeted hornbill (Rhinoplax vigil) is notable for its casque (a bulbous beak protrusion) being filled with trabeculae and fronted by a very thick keratin layer. Casque function is debated but appears central to aerial jousting, where birds (typically males) collide casques at high speeds in a mid-flight display that is audible for more than 100 m. We characterized the structural relationship between the skull and casque anatomy using X-ray microtomography and quantitative trabecular network analysis to examine how the casque sustains extreme impact.
View Article and Find Full Text PDFArticle Synopsis
- This study focused on the connection between sepsis and periprosthetic joint infections (PJI) in the hip and knee, examining risk factors and outcomes associated with the condition.
- Among patients with PJI, 40.6% also had sepsis, with higher comorbidity indexes and specific infections like Staphylococcus aureus linked to increased sepsis risk, longer hospital stays, and higher mortality rates.
- The findings highlight the critical need for careful monitoring and prompt treatment for PJI patients to prevent severe complications and improve survival rates.
Article Synopsis
- Research on the vertical transmission of SARS-CoV-2 during pregnancy is limited, particularly for early pregnancy, making it hard to gauge risks for fetal health.
- A study using a 3D endometrial spheroid model found that SARS-CoV-2 can infect both non-decidualized and decidualized spheroids, leading to changes in chemokine levels and gene expression related to immune response.
- The findings suggest that these endometrial spheroids are a valuable model for studying the potential effects and implications of SARS-CoV-2 vertical transmission during pregnancy.
Incorporation of the central vein sign into the McDonald criteria.
Mult Scler Relat Disord
November 2024
Background: Diagnosis of multiple sclerosis (MS) frequently relies on MRI dissemination in time (DIT) and space (DIS), as codified in 2017 McDonald criteria (McD 2017). The central vein sign (CVS) is a proposed MS diagnostic biomarker, but its optimal incorporation into McD 2017 has not been extensively studied.
Objective: Evaluate the diagnostic performance of several methods incorporating CVS into McD 2017 radiological DIS criteria.