Publications by authors named "M M S Ismaiel"
Worldwide, stroke is a leading cause of long-term disability in adults. Alteplase is the only approved treatment for acute ischemic stroke (AIS) and results in an improvement in a third of treated patients. Most studies evaluated the post-alteplase haemorrhagic transformation of brain infarction as a homogeneous entity but we evaluated the predictors of each subtype of haemorrhagic transformation of brain infarction.
View Article and Find Full Text PDFBackground: Many studies evaluated the efficacy and safety of ticagrelor versus clopidogrel in patients with ischemic stroke; none of these trials included North African participants, and all of these trials comprised only participants who experienced transient ischemic attack (TIA) or minor stroke.
Objectives: We compared the efficacy and safety of ticagrelor versus clopidogrel in patients with first-ever noncardioembolic moderate or moderate-to-severe ischemic stroke.
Methods: Our trial involved 900 first-ever noncardioembolic patients with acute ischemic stroke (AIS) who randomly received either loading and maintenance doses of ticagrelor or clopidogrel within the first 24 h of stroke onset.
Article Synopsis
- Adiponectin is a promising non-invasive biomarker for liver cirrhosis, reflecting inflammation and metabolic changes, but its role remains unclear due to conflicting findings.
- A systematic review was conducted using 16 studies with 2617 participants, finding that adiponectin levels were significantly higher in liver cirrhosis patients, particularly in those classified as Child-Pugh B.
- The study concludes that while adiponectin is elevated in advanced liver cirrhosis, there are no significant differences when compared to hepatocellular carcinoma (HCC) patients, highlighting its potential as a diagnostic and prognostic tool.
Background: Several studies have examined the potential of adrenomedullin (ADM), pro-adrenomedullin (Pro-ADM), and mid-regional-pro-ADM (MR-Pro-ADM) as biomarkers for diagnosing and assessing the severity of heart failure (HF), with conflicting results. We aimed to investigate their diagnostic utility and their correlation with HF severity based on the New York Heart Association (NYHA) classification.
Methods: We searched PubMed, EMBASE, and Scopus using a predefined search string.
Background/aims: In recent years, the presence of alexithymia in patients with irritable bowel syndrome (IBS) has gained more attention, and several studies have evaluated this relationship. However, no clear conclusion has been reported yet. Therefore, we conducted a systematic review and meta-analysis to better understand the association between IBS and alexithymia.
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