Publications by authors named "M M Polidoro"
Background: Indicators of surgical outcomes are designed to objectively evaluate surgical performance, enabling comparisons among surgeons and institutions. In recent years, there has been a surge in complex indicators of perioperative short-term and long-term outcomes. The aim of this narrative review is to provide an overview and a critical analysis of surgical outcomes indicators, with a special emphasis on hepato-pancreato-biliary (HPB) surgery.
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- Systemic inflammation plays a crucial role in intrahepatic cholangiocarcinoma (iCCA), and this study investigates the prognostic importance of inflammatory indexes like the neutrophil-to-lymphocyte ratio (NLR) and lymphocyte-to-monocyte ratio (LMR).
- A total of 101 iCCA patients were analyzed, revealing that higher NLR and lower LMR correlate with worse survival outcomes; those with high-risk profiles had significantly lower 5-year overall survival rates compared to low-risk patients.
- Flow cytometry results showed distinct immune cell profiles, with high-risk patients having more CD4+ T-cells and fewer CD8+ T-cells, suggesting inflammatory indexes can serve as indicators for tumor microenvironment and prognosis
Article Synopsis
- - Tumor-associated macrophages (TAMs) play a crucial role in the tumor microenvironment, with smaller TAMs (S-TAMs) linked to better prognosis in colorectal liver metastasis compared to larger TAMs (L-TAMs).
- - Research using multiparametric flow cytometry and metabolomics identified that L-TAMs show a strong association with riboflavin, which affects the enzyme lysine-specific demethylase 1A (LSD1) and plays a role in TAM morphology.
- - The study suggests that targeting the riboflavin-LSD1 relationship could reprogram TAM subtypes, offering new strategies for anti-tumor therapies.
Prevalence and Spatial Autocorrelation of Tuberculosis in Indigenous People in Brazil, 2002-2022.
J Racial Ethn Health Disparities
February 2024
Tuberculosis (TB) among indigenous populations in Brazil poses a multifaceted public health challenge influenced by geographical, social, institutional, economic, and cultural factors. This study scrutinized the prevalence and spatial distribution of TB among Brazilian indigenous communities from 2002 to 2022. Employing a cross-sectional and descriptive approach, we analyzed data from the Notifiable Diseases Information System (SINAN) and conducted spatial autocorrelation tests to identify clusters and outliers.
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