Publications by authors named "M M Picken"
Article Synopsis
- - Oncocytic renal neoplasms pose significant diagnostic challenges, yet are generally nonaggressive, prompting discussion about the necessity of differentiating emerging subtypes like eosinophilic solid and cystic renal cell carcinoma and others.
- - A survey of 63 urologic pathologists revealed that many encounter complex oncocytic tumors frequently, with 70% agreeing that eosinophilic solid and cystic renal cell carcinoma should be recognized as a distinct category, while opinions were more divided on other types.
- - Diagnostic approaches varied among pathologists, with 60% hesitant to diagnose oncocytoma through needle biopsies, and a near split on the routine use of immunohistochemistry; common genetic testing was
Hepatic glomerulosclerosis, a renal complication of liver cirrhosis, presents challenges in diagnosis and management. This case report discusses the rarity of kidney biopsy findings resembling lecithin-cholesterol acyltransferase (LCAT) deficiency post liver transplantation. We present the case of a patient with end-stage liver disease (ESLD) from alcohol-related cirrhosis, who underwent orthotopic liver transplantation (OLT) with persistent proteinuria after transplantation.
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- * The survey received an 85% response rate from 98 uropathologists, revealing strong agreement on distinguishing between luminal and basal UC types, but varied opinions on the importance of certain genetic tests like FGFR3 and TERT promoter mutations.
- * Most uropathologists acknowledged the aggressive nature of tumors with micropapillary features and favored further evaluation and specific molecular testing for aggressive subtypes, indicating a need for improved consensus in UC classification and treatment strategies.
Nephrogenic adenoma (NA) is a benign, reactive lesion seen predominantly in the urinary bladder and often associated with antecedent inflammation, instrumentation, or an operative history. Its histopathologic diversity can create diagnostic dilemmas and pathologists use morphologic evaluation along with available immunohistochemical (IHC) markers to navigate these challenges. IHC assays currently do not designate or specify NA's potential putative cell of origin.
View Article and Find Full Text PDFPurpose: Few studies have quantified differences in histology and implications for survival between male children and adults with germ cell tumors (GCT). We evaluated these differences and associations with cancer-specific survival (CSS) using Surveillance, Epidemiology, and End Results (SEER) cancer registries.
Methods: SEER (1988-2016) was used to identify male patients 0 to 40 years of age diagnosed with seminoma and nonseminomatous GCT (NSGCT).