Antimicrobial stewardship: a definition with a One Health perspective.

Antimicrobial stewardship (AMS) is a commonly advocated approach to address antimicrobial resistance. However, AMS is often defined in different ways depending on where it is applied, such that a range of definitions is now in use. These definitions may be functional and well-structured for a given context but are often ill-adapted for collaborative work, creating difficulties for intersectoral communication on AMS and complicating the design, implementation, and evaluation of AMS interventions from a One Health perspective.

Reprocessable and Recyclable Materials for 3D Printing via Reversible Thia-Michael Reactions.

The development of chemically recyclable polymers for sustainable 3D printing is crucial to reducing plastic waste and advancing towards a circular polymer economy. Here, we introduce a new class of polythioenones (PCTE) synthesized via Michael addition-elimination ring-opening polymerization (MAEROP) of cyclic thioenone (CTE) monomers. The designed monomers are straightforward to synthesize, scalable and highly modular, and the resulting polymers display mechanical performance superior to commodity polyolefins such as polyethylene and polypropylene.

Munsell Soil Colour Prediction from the Soil and Soil Colour Book Using Patching Method and Deep Learning Techniques.

Soil colour is a key indicator of soil health and the associated properties. In agriculture, soil colour provides farmers and advises with a visual guide to interpret soil functions and performance. Munsell colour charts have been used to determine soil colour for many years, but the process is fallible, as it depends on the user's perception.

Mutations in histones dysregulate copper homeostasis leading to defect in Sec61 dependent protein translocation mechanism in Saccharomyces cerevisiae.

The translocation of proteins from the cytoplasm to the endoplasmic reticulum occurs via a conserved Sec61 protein channel. Previously, we reported that mutations in histones cause downregulation of a CUP1 copper metallothionein and copper exposure inhibits the activity of Sec61. However, the role of epigenetic dysregulation on the activity of channel is not clear.