Evaluating the effect of amalgam fillings on caries detection in cone-beam computed tomography images.

Background: Dental caries stands as one of the most prevalent dental concerns, with early diagnosis being pivotal in clinical dentistry. Cone-beam computed tomography (CBCT) emerges as a widely utilized modality for dental caries identification, owing to its significant advantages. However, there remains a considerable knowledge gap regarding the efficacy of CBCT scans in detecting dental caries.

Recovery of antimony from acidic and alkaline leaching solution of low-grade antimony ore by electrowinning process.

With regards to the global continuous growth in consumption of base metals such as antimony (Sb), mining companies are currently looking to improve the productivity and extraction of Sb from low grade ore in order to economically process it. With this aim, in this study, an efficient protocol was developed to recover metallic Sb from the low grade FeSiO(OH). SbO(OH).

Spatial intra-tumour heterogeneity and treatment-induced genomic evolution in oesophageal adenocarcinoma: implications for prognosis and therapy.

Background: Oesophageal adenocarcinoma (OAC) is a highly heterogeneous cancer with poor survival. Standard curative treatment is chemotherapy with or without radiotherapy followed by oesophagectomy. Genomic heterogeneity is a feature of OAC and has been linked to treatment resistance.

Temporally resolved proteomics identifies nidogen-2 as a cotarget in pancreatic cancer that modulates fibrosis and therapy response.

Pancreatic ductal adenocarcinoma (PDAC) is characterized by increasing fibrosis, which can enhance tumor progression and spread. Here, we undertook an unbiased temporal assessment of the matrisome of the highly metastatic KPC (, , ) and poorly metastatic KPC (, , ) genetically engineered mouse models of pancreatic cancer using mass spectrometry proteomics. Our assessment at early-, mid-, and late-stage disease reveals an increased abundance of nidogen-2 (NID2) in the KPC model compared to KPC, with further validation showing that NID2 is primarily expressed by cancer-associated fibroblasts (CAFs).