Genu Varum Correction with HA Filler Volumisation of the Medial Gastrocnemius.

Background: Genu varum, or bow-legged deformity, involves an outward curvature of the lower limbs, often creating a visible gap between the knees when the ankles are together. Traditionally treated with invasive surgical methods like high tibial osteotomy, genu varum correction now includes less invasive options for patients with mild to moderate deformities. This commentary explores a novel approach using hyaluronic acid (HA) filler to volumise the medial gastrocnemius muscle, thereby improving calf contour and stability without surgery.

Treatment of the Temples: Brazilian Consensus.

Introduction: The temporal region is emblematic and challenging due to its structural and volumetric changes during aging, which significantly affect facial aesthetics. Despite the importance of addressing temporal aging, many injectors hesitate due to the region's anatomical complexity and risk of complications. This consensus aimed to provide expert guidance on the safest and most effective treatment strategies for the temple.

Unveiling the Antimycobacterial Potential of Novel 4-Alkoxyquinolines: Insights into Selectivity, Mechanism of Action, and Exposure.

This work presents a comprehensive investigation into the design, synthesis, and evaluation of a novel series of 4-alkoxyquinolines as potential antimycobacterial agents. The design approach, which combined molecular simplification and chain extension, resulted in compounds with potent and selective activity against both drug-susceptible and multidrug-resistant strains. The lead molecule, targeting the cytochrome complex, exhibited favorable kinetic solubility and remarkable chemical stability under acidic conditions.

Development and validation of a face database for the recognition of facial expressions of basic emotions in the Brazilian population.

Background: The recognition of facial expressions of emotions is an essential skill for social functioning, as it enables recognizing the possible intentions of others.

Main Body: Cultural context is an important aspect to consider in this skill, as it tends to modulate the recognition of facial expressions.

Objective: To develop and validate a set of facial expressions of basic emotions of Brazilian individuals considering the population distribution of the country according to age group, sex, and race.

Treatment of Mid-Face Aging with Calcium Hydroxylapatite: Focus on Retaining Ligament Support.

The mid-face has been rendered as the cornerstone of facial aesthetic improvement, since treating the mid-face has also beneficial effects on neighboring esthetic units and therefore should be one of the first areas to be assessed. Retaining ligaments (RL) bind soft tissue layers of the face to the underlying facial skeleton. It remains controversial whether RL suffers laxity with aging or if changes in 42 bone and other structures where ligaments are inserted lead to altered mechanical function of the latter.