Computational Evaluation of Fusarium nygamai Compounds as AcrD Efflux Pump Protein Inhibitors of Salmonella Typhimurium.

In Salmonella Typhimurium, efflux pump proteins, such as AcrD actively expel drugs and hazardous chemicals from bacterial cells, resulting in treatment failure and the emergence of antibiotic-resistant variants. Focusing on AcrD may lead to the development of novel antimicrobials against multidrug-resistant bacteria. However, challenges persist in achieving high selectivity, low toxicity, and effective bacterial penetration.

Comprehensive surgical management of a severe 270-degree circumferential penetrating neck injury from an industrial accident: a case report.

Penetrating neck injury (PNI), involving disruption of the platysma muscle, accounts for 10% of trauma cases and poses significant morbidity and mortality risks. This case report details the management of a 45-year-old male who sustained a 270-degree circumferential neck incision from an industrial accident. The patient presented with a deep neck laceration, severe blood loss, and hypovolemic shock.

Surgical pearl: The "dumbbell" technique: An attempt to simplify nail dressing.

A stable and less voluminous nail dressing is required after nail surgery over the nail unit. The bandage should take care of trauma, water and discharge from the wound. We described the use of two layered non-sticky and absorptive bandages.

Mentor-Mentee relationship in Medicine: How to develop trust?

A mentor-mentee relationship, also known as a mentoring relationship, is a professional or personal partnership in which a more experienced or knowledgeable individual (the mentor) provides guidance, support, and advice to a less experienced or knowledgeable individual (the mentee). The primary purpose of this relationship is to facilitate the mentee's personal and professional growth. Mentors typically share their expertise, wisdom, and experiences to help mentees navigate their career or personal development paths.