[Clinical effectiveness and pharmacokinetics of gliflozin from the point of view of individual genetic characteristics: A review].

A review of publications devoted to the analysis of genetic polymorphisms and features of the functioning of genes that affect the pharmacokinetics and pharmacodynamics of sodium-glucose cotransporter-2 inhibitors (SGLT2i) is presented. Objective of the study was to reveal information about genes whose polymorphism may affect the effectiveness of SGLT2i. The review was carried out in accordance with the PRISMA 2020 recommendations, the search for publications was carried out in the PubMed databases (including Medline), Web of Science, as well as Russian scientific electronic libraries eLIBRARY.

[The rhythm-modulant effect of lithium hydroxybutyrate on the background of electrolytic lesion of the right suprachiasmatic nucleus of hypothalamus].

Experimental lesion of the right suprachiasmatic nucleus of hypothalamus in rats facilitates manifestations of the free-running locomotor rhythm in winter solstice, but decreases the entrainment of the light cycle of this rhythm in the period of summer solstice. The administration of lithium hydroxybutyrate in both illumination regimes compensates the influence of lesion of the right suprachiasmatic nucleus. Features of the observed effect depend on the circadian phase of drug administration.

[Effect of lithium hydroxybutyrate on the circadian dynamics of the urinary excretion of Li(+), Na(+), K(+), and Ca(2+) in rats depending on the circadian phase of the drug administration].

In winter solstice, the urinary excretion of Li+ and Na+ in intact rats has a uniform circadian profile, while K+ and Ca2+ exhibit a 23-h and 24-h rhythm, respectively. The administration of lithium hydroxybutyrate (10 mg/kg, 6 days) at 8 a.m.