Publications by authors named "M M McClellan"
Article Synopsis
- * A new technique called polymerase error rate sequencing (PER-seq) was developed to measure DNA polymerase error rates, revealing that a common Pol ε mutant (P286R) significantly increases CpG>TpG errors similar to those seen in cancer tumors.
- * Wild-type Pol ε shows a much higher error rate when replicating 5mCpG as opposed to regular cytosines, indicating that replication errors represent a crucial factor in CpG>TpG mutagenesis and altering the
Clinical evidence generation from and for representative populations can be improved through increased research access and ease of trial participation. To improve access and participation, a modern trial infrastructure is needed that broadens research into more routine practice. This commentary highlights current barriers, areas of advancement, and actions needed to enable continued transformation toward a modern trial infrastructure for an improved evidence generation system.
View Article and Find Full Text PDFDisparities in access to health care are persistent and contribute to poor health outcomes for many populations around the world. Barriers to access are often similar across countries, despite differences in how health systems are structured. Health care leaders can work to address these barriers through bold, evidence-based actions.
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