Publications by authors named "M M Mazzotta"
Background/objectives: HER2-positive breast cancer (HER2BC) is an aggressive subtype, with neoadjuvant treatment (NAT) aiming to achieve a pathological complete response (pCR) to improve long-term outcomes. Trastuzumab emtansine (T-DM1) has been established as the standard of care in the adjuvant setting for HER2BC patients who do not obtain pCR. The ATD study aimed to evaluate the real-world tolerability of T-DM1 in this setting.
View Article and Find Full Text PDF[ST-elevation myocardial infarction caused by stent fracture: a case report].
G Ital Cardiol (Rome)
November 2024
Coronary stent fracture is an infrequent event, with an incidence ranging from 1% to 8%. In rare cases, this complication may result in acute occlusion of the affected coronary artery. We report the case of a patient who experienced acute coronary syndrome following a stent fracture implanted 3 years previously.
View Article and Find Full Text PDFArticle Synopsis
- A patient with mevalonate kinase deficiency (MKD), an autoinflammatory disease, displayed two gene variants linked to the condition and suffered from recurrent periodic fevers and multiple organ symptoms, particularly a form of kidney disease called IgA nephropathy.
- Despite various immunosuppressive treatments over seven years, the patient found effective relief only after starting canakinumab, a medication targeting inflammation.
- Complications arose from a severe kidney event after an infection, raising questions about how MKD-related inflammation might interact with kidney disease, suggesting a possible connection between the patient's symptoms and underlying disease processes.
Purpose: Co-occurring mutations in KEAP1 and STK11/KRAS have emerged as determinants of survival outcomes in patients with non-small cell lung cancer (NSCLC) treated with immunotherapy. However, these mutational contexts identify a fraction of nonresponders to immune checkpoint inhibitors. We hypothesized that KEAP1 wild-type tumors recapitulate the transcriptional footprint of KEAP1 mutations and that this KEAPness phenotype can determine immune responsiveness with higher precision compared to mutation-based models.
View Article and Find Full Text PDFPrevalence and clinical outcomes of isolated or combined moderate to severe mitral and tricuspid regurgitation in patients with cardiac amyloidosis.
Eur Heart J Cardiovasc Imaging
June 2024
Article Synopsis
- The study focused on the prevalence and impact of mitral regurgitation (MR) and tricuspid regurgitation (TR) in patients with cardiac amyloidosis (CA), highlighting a lack of existing research on this topic.
- Among 538 patients analyzed, 44.6% had no significant MR/TR, while a significant portion experienced varying degrees of MR or TR, with common causes being atrial functional issues and right ventricular overload.
- Results indicated that patients with MR/TR had worse health outcomes, including higher hospitalization rates for heart failure, more symptoms, and increased risk of death or worsening heart failure, with TR presenting the most severe risks.