Development and validation of a checklist for cardiopulmonary bypass.

Introduction: Risk prevention protocols related to patient care have been developed to reduce the incidence of adverse events in health care services. Cardiopulmonary bypass (CPB) can trigger several complications, including physiological problems, electrical, mechanical, and human failures, or defective components. In order to promote patient safety and the identification of failures before they can cause damage, it is necessary to the use of a checklist for all surgeries.

What can we learn about the impact of cancelled planned operations on waiting times? A case study using the 2017/18 winter flu postponement policy in England.

Background: Cancelled operations can potentially impact both health and patient experience through their effect on waiting times. However, identifying causal relationships is challenging. One possible solution is to consider 'exogenous shocks' to the system as a type of natural experiment to quantify impacts.

Developing an algorithm to identify individuals with psychosis in secondary care in England: application using the Mental Health Services Data Set.

Background: There is currently no definitive method for identifying individuals with psychosis in secondary care on a population-level using administrative healthcare data from England.

Aims: To develop various algorithms to identify individuals with psychosis in the Mental Health Services Data Set (MHSDS), guided by national estimates of the prevalence of psychosis.

Method: Using a combination of data elements in the MHSDS for financial years 2017-2018 and 2018-2019 (mental health cluster (a way to describe and classify a group of individuals with similar characteristics), Health of the Nation Outcome Scale (HoNOS) scores, reason for referral, primary diagnosis, first-episode psychosis flag, early intervention in psychosis team flag), we developed 12 unique algorithms to detect individuals with psychosis seen in secondary care.

[Clinical research in oncology in French Overseas Territories: Challenges, strengths, and available resources].

Introduction: Reducing territorial inequalities in access to care and innovations in oncology is an objective of the ten-year strategy to fight cancer. The populations of Overseas Territories (OT) face limits in terms of access to clinical research in oncology (CRO).

Methods: The article aims to share an exhaustive inventory of the challenges observed in the development of CRO in the OT but also the means identified to respond to them, illustrated with recent successes in terms of setting up a CRO program.

Clinical outcomes and management following progressive disease with anti-PD-(L)1 therapy in patients with advanced Merkel Cell Carcinoma.

Aim: Merkel Cell Carcinoma (MCC) is a rare skin cancer with a rising incidence worldwide. Anti-programmed death-1/ligand-1 (anti-PD-(L)1) therapies are effective for the treatment of advanced MCC. This study examines patterns of response / progression of advanced MCC to anti-PD-(L)1 therapies and describes subsequent management.