Modular Synthesis of Anti-HER2 Dual-Drug Antibody-Drug Conjugates Demonstrating Improved Toxicity.

Antibodies have gained clinical success in the last two decades for the targeted delivery of highly toxic small molecule chemotherapeutics. Yet antibody-drug conjugates (ADCs) often fail in the clinic due to the development of resistance. The delivery of two mechanistically distinct small molecule drugs on one antibody is of increasing interest to overcome these challenges with single-drug ADCs.

Effectiveness of cognitive functional therapy (CFT) for chronic spinal pain: a systematic review with meta-analysis.

Objective: To assess the effectiveness of cognitive functional therapy (CFT) in reducing disability and pain compared to other interventions in chronic spinal pain patients.

Methods: Five databases were queried to October 2023 for retrieving randomized controlled trials (RCTs), including patients with chronic spinal pain and administering CFT. Primary outcomes were disability and pain.

Cracking arbitrariness: A data-driven study of auditory iconicity in spoken English.

Auditory iconic words display a phonological profile that imitates their referents' sounds. Traditionally, those words are thought to constitute a minor portion of the auditory lexicon. In this article, we challenge this assumption by assessing the pervasiveness of onomatopoeia in the English auditory vocabulary through a novel data-driven procedure.

CO and Temperature Induced Switching of a Flexible Metal-Organic Framework with Surface-Mounted Nanoparticles.

Within the material family of metal-organic frameworks (MOFs) the subclass of flexible MOFs (flexMOFs) has attracted great attention, showing structural flexibility as a response to external stimuli such as guest adsorption, temperature, and pressure. Hybrid composites like nanoparticle (NP) loaded flexible MOFs, which stand to potentially combine advantageous properties of both are yet largely unexplored. Here the synthesis of flexMOFs with surface mounted nanoparticles, e.

The Italian Crowdsourcing Project: Visual word recognition times for 130,495 Italian words.

Despite being largely spoken and studied by language and cognitive scientists, Italian lacks large resources of language processing data. The Italian Crowdsourcing Project (ICP) is a dataset of word recognition times and accuracy including responses to 130,465 words, which makes it the largest dataset of its kind item-wise. The data were collected in an online word knowledge task in which over 156,000 native speakers of Italian took part.