Publications by authors named "M M Machulda"
Progressive supranuclear palsy (PSP) can present with different clinical variants which show distinct, but partially overlapping, patterns of neurodegeneration and tau deposition in a network of regions including cerebellar dentate, superior cerebellar peduncle, midbrain, thalamus, basal ganglia, and frontal lobe. We sought to determine whether disruptions in functional connectivity within this PSP network measured using resting-state functional MRI (rs-fMRI) differed between PSP-Richardson's syndrome (PSP-RS) and the cortical and subcortical clinical variants of PSP. Structural MRI and rs-fMRI scans were collected for 36 PSP-RS, 25 PSP-cortical and 34 PSP-subcortical participants who met the Movement Disorder Society PSP clinical criteria.
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- This study investigates the limitations of the 2011 consensus criteria for primary progressive aphasia (PPA), specifically focusing on features of logopenic variant PPA and aiming to refine the classification system based on clinical and neuroimaging data.
- A retrospective analysis of 102 PPA patients revealed a predominance of repetition-preserved variants over repetition-impaired ones, suggesting different clinical courses and potential prodromal stages among the subgroups identified (pure-LPA, Wernicke-like, anomic-like, and TCSA-like).
- Neuroimaging showed consistent left temporoparietal atrophy across groups, with severe hypometabolism linked to repetition deficits, while pathologically, 70% of patients had Alzheimer's disease, with varying
Objectives: To describe a case of spinocerebellar ataxia presenting with progressive apraxia of speech (AOS).
Methods: A 54-year-old man with progressive speech changes was seen clinically and referred to our observational research program on degenerative speech and language disorders. He underwent detailed speech-language and neurologic assessments and multimodal neuroimaging studies.
Article Synopsis
- Obstructive sleep apnoea (OSA) is linked to a higher risk of cognitive impairment and dementia, potentially involving Alzheimer's disease pathology.
- This study focused on the relationship between sleep patterns (specifically non-rapid eye movement slow-wave activity or SWA) and the accumulation of amyloid, a protein associated with Alzheimer's, in older adults with OSA.
- The results showed that increased slow oscillation (SO) activity in sleep was correlated with greater amyloid accumulation, while certain sleep patterns also indicated a potential reduction in amyloid buildup.
Article Synopsis
- - The study examines the relationship between amyloid beta (Aβ) PET scans and Aβ biomarkers in cerebrospinal fluid (CSF) to assess their effectiveness in treating Aβ-related conditions.
- - A total of 505 participants aged 50 and older were analyzed, with a focus on their Aβ levels as measured by both PET and CSF, and a subgroup of 47 who underwent autopsy for further validation.
- - Results indicated that Aβ PET scans detected earlier Aβ accumulation in the brain compared to CSF biomarkers, showing a higher sensitivity for identifying early stages of Aβ deposition.