Reflections on using methodology to engage with Pacific youth in Aotearoa New Zealand about their sexual and reproductive health.

Pacific understandings of sexual and reproductive health (SRH) encompass beliefs and practices reflective of Pacific values systems. These are integral to cultural understandings of safety, relationships, and intimacy. Research processes and practices that appropriately address these values and sensitives are scarcely available in the literature, leading to limited use and understanding of culturally appropriate methods and procedures.

Obesity modulates NK-cell activity via LDL & DUSP1 signaling for Populations with Adverse Social Determinants.

African American (AA) women are disproportionally affected by obesity and hyperlipidemia, particularly in the setting of adverse social determinants of health (aSDoH) contributing to health disparities. Obesity, hyperlipidemia, and aSDoH appear to impair Natural Killer cells (NKs). As potential common underlying mechanisms are largely unknown, we sought to investigate common signaling pathways involved in NK dysfunction related to obesity and hyperlipidemia in AA women from under-resourced neighborhoods.

Effects of cladribine on intrathecal and peripheral B and plasma cells.

Introduction: Cladribine is a deoxyadenosine analogue that can penetrate the blood-brain barrier. It is used to treat multiple sclerosis (MS). However, the mechanistic understanding of the effect of this highly effective therapy on B cells and plasma cells in the central nervous system compartment is limited.