[Arterial Hypertension and Methylenetetrahydrofolate Reductase C677T Gene Polymorphism].

Objective: to determine the association of polymorphisms of C677T methylenetetrahydrofolate reductase (MTHFR) gene with essential arterial hypertension (EH) in the group of patients of Belarusian ethnicity.

Methods: The clinical examination and molecular genetic study of the polymorphism C677T of MTHFR gene by polymerase chain reaction and restriction fragment length polymorphism analysis were performed in 423 people, including 315 patients with EH and 108 healthy individuals.

Results: The distribution of C and T alleles of polymorphism C677T of the MTHFR gene in hypertensive patients was 67.

[Effect of an acute pharmacological test and a course of treatment with nifedipine on cerebral hemodynamic indices and information processing efficiency in hypertension patients].

Acute nifedipine tests and courses of nifedipine treatment were conducted in 30 patients with essential hypertension. The response of arterial blood pressure and cerebral hemodynamics to the acute test coincided with the results of a treatment course. The hypotensive effect, associated with nifedipine treatment, is combined with favorable cerebral hemodynamic changes and an increase in mental performance of hypertensive patients.