Vaginal fungi are associated with treatment-induced shifts in the vaginal microbiota and with a distinct genital immune profile.

Vaginal colonization by fungi may elicit genital inflammation and enhance the risk of adverse reproductive health outcomes, such as HIV acquisition. Cross-sectional studies have linked fungi with an absence of bacterial vaginosis (BV), but it is unclear whether shifts in vaginal bacteria alter the abundance of vaginal fungi. Vaginal swabs collected following topical metronidazole treatment for BV during the phase 2b, placebo-controlled trial of LACTIN-V, a -based live biotherapeutic, were assayed with semi-quantitative PCR for the relative quantitation of fungi and key bacterial species and multiplex immunoassay for immune factors.

Vaginal Lactobacillus crispatus persistence following application of a live biotherapeutic product: colonization phenotypes and genital immune impact.

Background: Bacterial vaginosis (BV) increases HIV acquisition risk, potentially by eliciting genital inflammation. After BV treatment, the vaginal administration of LACTIN-V, a live biotherapeutic containing the Lactobacillus crispatus strain CTV-05, reduced BV recurrence and vaginal inflammation; however, 3 months after product cessation, CTV-05 colonization was only sustained in 48% of participants.

Results: This nested sub-study in 32 participants receiving LACTIN-V finds that 72% (23/32) demonstrate clinically relevant colonization (CTV-05 absolute abundance > 10 CFU/mL) during at least one visit while 28% (9/32) of women demonstrate colonization resistance, even during product administration.

Direct Homogeneous Synthesis of Compounds with Two O Atoms and Long-Chain Hydrocarbons from CO and H: Co-Ru/N-methylpyrrolidone Catalyst.

The homogeneous acetic acid synthesis-type Ru-Co-Li/N-methylpyrrolidone catalyst for CO and H transformations has been studied at moderately high pressures. For 1CO:2H, low acetic acid selectivity has been observed, along with remarkable methyl acetate selectivity, the absence of aldehydes and ethyl acetate and sharp deviations from the Anderson-Schultz-Flory distribution for both alcaohols and long-chain hydrocarbons. For 1CO:1H and slightly elevated pressure, acetic acid selectivity slightly increased, notable ethyl acetate formation was detected, and both long-chain hydrocarbons and alcohols disappeared.

Catalytic Design of Matrix-Isolated Ni-Polymer Composites for Methane Catalytic Decomposition.

Targeted synthesis of C/composite Ni-based material was carried out by the method of matrix isolation. The composite was formed with regard to the features of the reaction of catalytic decomposition of methane. The morphology and physicochemical properties of these materials have been characterized using a number of methods: elemental analysis, scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), Raman spectroscopy, temperature programmed reduction (TPR-H), specific surface areas (SSA), thermogravimetric analysis, and differential scanning calorimetry (TGA/DSC).

Study of the Possibility of Using Sol-Gel Technology to Obtain Magnetic Nanoparticles Based on Transition Metal Ferrites.

The article presents results for the magnetic nanoparticles sol-gel method synthesis of cobalt (II) ferrite and organic-inorganic composite materials based on it. The obtained materials were characterized using X-ray phase analysis, scanning and transmission electron microscopy, Scherrer, Brunauer-Emmett-Teller (BET) methods. A composite materials formation mechanism is proposed, which includes a gelation stage where transition element cation chelate complexes react with citric acid and subsequently decompose under heating.