Graphene Oxide Sheets Decorated with Octahedral Molybdenum Cluster Complexes for Enhanced Photoinactivation of .

The emergence of multidrug-resistant microbial pathogens poses a significant threat, severely limiting the options for effective antibiotic therapy. This challenge can be overcome through the photoinactivation of pathogenic bacteria using materials generating reactive oxygen species upon exposure to visible light. These species target vital components of living cells, significantly reducing the likelihood of resistance development by the targeted pathogens.

Multimodal-Driven Magnetic Microrobots with Enhanced Bactericidal Activity for Biofilm Eradication and Removal from Titanium Mesh.

Modern micro/nanorobots can perform multiple tasks for biomedical and environmental applications. Particularly, magnetic microrobots can be completely controlled by a rotating magnetic field and their motion powered and controlled without the use of toxic fuels, which makes them most promising for biomedical application. Moreover, they are able to form swarms, allowing them to perform specific tasks at a larger scale than a single microrobot.

A Cell Membrane Targeting Molybdenum-Iodine Nanocluster: Rational Ligand Design toward Enhanced Photodynamic Activity.

The development of singlet oxygen photosensitizers, which target specific cellular organelles, constitutes a pertinent endeavor to optimize the efficiency of photodynamic therapy. Targeting of the cell membrane eliminates the need for endocytosis of drugs that can lead to toxicity, intracellular degradation, or drug resistance. In this context, we utilized copper-free click chemistry to prepare a singlet oxygen photosensitizing complex, made of a molybdenum-iodine nanocluster stabilized by triazolate apical ligands.

Emergence of Five Genetic Lines ST395, ST13, ST3346, ST39, and Novel ST3551 of Multidrug-Resistant Clinical in Russia.

The objective of this study was phenotypic and genotypic characterization of antibacterial-resistant clinical strains isolated in Moscow Transplantology Intensive Care Unit in 2017-2019. Major strains among ( = 63) isolated from 30 patients were recognized as extensive drug-resistant ( = 55) pathogens, and remaining strains were recognized as multidrug-resistant ( = 8) pathogens. The beta-lactamase genes ( = 63), ( = 61), ( = 54), ( = 52), and ( = 2), as well as class 1 integrons ( = 19) carried gene cassette arrays A4 ( = 2), A1C ( = 6), BA1 ( = 9), A15A1 ( = 3), and A12 ( = 1) were identified in the strains.

Antibiotic Activity of Probiotic Strain Bacillus subtilis 534 Against Clinical Isolates of Acinetobacter baumannii.

Probiotic strain Bacillus subtilis 534 is the base of sporobacterin, a pharmaceutical. In submerged culture it showed antibiotic activity against many of gram-positive and gram-negative bacteria and fungi. The spectrum of the antimicrobial activity of the culture fluid depended on the.