[Evaluation of the effectiveness of treatment of patients with nonspecific pain syndrome in the lower back with celecoxib and a combined preparation of B vitamins].

Objective: To evaluate the effectiveness of the effect of celecoxib and the combined vitamin complex of group B in comparison with meloxicam in patients with acute and chronic nonspecific lumbar pain (LP).

Material And Methods: The effectiveness of the effect on acute (44%; acute pain syndrome (APS)) and chronic (56%; chronic pain syndrome (CPS)) LP of moderate intensity (according to VAS/MPQ) (APS 5.7±2.

[Structural-functional approach to chronic cerebral ischemia in elderly people.].

The aim of the study - experience in implementing a structural-functional approach to chronic brain ischemia (CCI) in elderly people by combining simultaneously produced measurements. Object of research - elderly patients with CCI 1 stage. As a result of the study, the methodological experience of the system study of CCI from the standpoint of the structural and functional approach in the elderly is shown.

[Clinical experience of the use of agomelatine in the treatment of patients with depression and chronic brain ischemia].

Objective: To study the efficacy and tolerability of agomelatine (valdoxan) in treatment of mild depressive states in patients with chronic brain ischemia (CBI).

Material And Methods: The study comprised 33 patients (23 women, 10 men, average age 54.5 years), including 12 people (36.

[Activity of genetically programmed cell death of lymphocytes in rheumatoid arthritis].

Aim: To study activity of genetically programmed cell death (PCD) of lymphocytes in patients with rheumatoid arthritis (RA).

Material And Methods: Lymphocytes from 30 RA patients including 14 patients with RA history up to 2 years, and 12 healthy donors were studied for activity of caspase 4, 6, 8 usingfluorescence and caspase substrates 30, 60, 120, 150 and 180 min after start of the reaction and number of 1-2-thread serration of DNA with fluorescence of two DNA-tropic stains--EtBr and 4,6-DAPY Correlation was also studied between lymphocyte activity and RA activity, x-ray stage, duration, level of TNF-alpha. The trend in PCD activity of lymphocytes in immunosuppressive therapy was analysed.