Publications by authors named "M M Kolar"
Objectives: Staphylococcus aureus is part of the human microbiota, but at the same time, it is capable of causing a wide range of diseases. Due to the ever-increasing resistance to antimicrobial agents and the existence of methicillin-resistant S. aureus (MRSA) strains, there is a real possibility of carrying even this resistant bacterium, which can subsequently cause a severe infection.
View Article and Find Full Text PDFObjective: This study aimed to evaluate the occurrence of methicillin-resistant Staphylococcus aureus (MRSA) at the University Hospital Olomouc (UHO) over a 10-year period (2013-2022).
Material And Methods: Data was obtained from the ENVIS LIMS laboratory information system (DS Soft, Czech Republic, Olomouc) of the Department of Microbiology, UHO, for the period 1/1/2013-31/12/2022. Standard microbiological procedures using the MALDI-TOF MS system (Biotyper Microflex, Bruker Daltonics) were applied for the identification.
L. (AE) has a rich tradition of use in wound healing improvement across various cultures worldwide. In previous studies, we revealed that L.
View Article and Find Full Text PDFWound healing represents a complex and evolutionarily conserved process across vertebrates, encompassing a series of life-rescuing events. The healing process runs in three main phases: inflammation, proliferation, and maturation/remodelling. While acute inflammation is indispensable for cleansing the wound, removing infection, and eliminating dead tissue characterised by the prevalence of neutrophils, the proliferation phase is characterised by transition into the inflammatory cell profile, shifting towards the prevalence of macrophages.
View Article and Find Full Text PDFArticle Synopsis
- Liquid-liquid phase separation in the cell nucleus plays a key role in gene regulation, chromatin organization, and DNA repair processes.
- The study utilized lipid-interacting RNA sequencing (LIPRNAseq) and confocal microscopy to explore the interaction of phosphatidylinositol 4,5 bisphosphate (PIP2) with specific RNA, identifying a PIP2-binding RNA motif and its colocalization with long non-coding RNA HANR in the perinucleolar compartment.
- The findings suggest a link between PIP2, lncHANR, and oncogenic super-enhancers, indicating their potential as prognostic markers for cancer and highlighting the importance of understanding lipid metabolism and RNA interactions for future cancer treatment strategies.