Publications by authors named "M M Kavurma"
Reversal of ischemia is mediated by neo-angiogenesis requiring endothelial cell (EC) and pericyte interactions to form stable microvascular networks. We describe an unrecognized role for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) in potentiating neo-angiogenesis and vessel stabilization. We show that the endothelium is a major source of TRAIL in the healthy circulation compromised in peripheral artery disease (PAD).
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- The study explores the role of inflammatory cytokines and receptors—specifically TRAIL, IL-18, and OPG—in predicting atherosclerotic coronary artery disease (CAD), especially when traditional risk factors are absent.
- It involved analyzing serum biomarker levels from 993 participants to see how these markers correlated with the severity of CAD as determined by CT scans.
- Although some associations were found between these inflammatory markers and CAD scores, they did not remain significant when adjusted for other risk factors like age, sex, and family history, indicating they may not be reliable standalone predictors of CAD.
Background: Hepatocellular carcinoma (HCC) remains a leading life-threatening health challenge worldwide, with pressing needs for novel therapeutic strategies. Sphingosine kinase 1 (SphK1), a well-established pro-cancer enzyme, is aberrantly overexpressed in a multitude of malignancies, including HCC. Our previous research has shown that genetic ablation of Sphk1 mitigates HCC progression in mice.
View Article and Find Full Text PDFPeripheral artery disease (PAD) is caused by blocked arteries due to atherosclerosis and/or thrombosis which reduce blood flow to the lower limbs. It results in major morbidity, including ischemic limb, claudication, and amputation, with patients also suffering a heightened risk of heart attack, stroke, and death. Recent studies suggest women have a higher prevalence of PAD than men, and with worse outcomes after intervention.
View Article and Find Full Text PDFTNF-related apoptosis-inducing ligand (TRAIL) was originally discovered, almost 20 years ago, for its ability to kill cancer cells. More recent evidence has described pleiotropic functions, particularly in the cardiovascular system. There is potential for TRAIL concentrations in the circulation to act as prognostic and/or diagnostic factors for cardiovascular diseases (CVD).
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