Integrin-α5 expression and its role in non-small cell lung cancer progression.

Integrins are transmembrane receptors that facilitate cell adhesion to the extracellular matrix and neighboring cells. Aberrant expression of integrins has been associated with tumor progression and metastasis in various cancer types. Integrin alpha-5 (ITGA5) is an integrin subtype that serves as a receptor for fibronectin, fibrinogen, and fibrillin-1.

COMPARATIVE STUDY BETWEEN DIABETIC AND NONDIABETIC CORONARY PATIENTS IN CARDIOVASCULAR REHABILITATION IN DAKAR, SENEGAL.

Introduction: Cardiac rehabilitation is crucial in managing coronary disease, particularly in type 2 diabetes, yet it remains almost non-existent in West Africa.

Objectives: This study aimed to compare the profiles of diabetic and non-diabetic coronary patients undergoing cardiac rehabilitation at the Principal Hospital of Dakar, Senegal.

Methodology: A comparative, descriptive, and analytical study was conducted from January 2019 to December 2022 involving two groups of coronary patients (diabetic and nondiabetic) at the rehabilitation centre.

PREVALENCE AND CLINICAL PROFILE OF VENOUS THROMBOEMBOLIC DISEASE IN A TERTIARY CENTER IN DAKAR.

Background: Venous thromboembolic disease (VTE) comprises deep vein thrombosis (DVT) and pulmonary embolism (PE) and ranks third among cardiovascular pathologies. Despite its growing burden in Africa, epidemiological data on VTE in Senegal is scarce. Conclusion: Venous thromboembolic disease is a prevalent and potentially severe condition, especially among relatively young individuals in our setting.

Modelling human diabetes : a glance at maturity onset diabetes of the young.

Diabetes is a complex metabolic disease which most commonly has a polygenic origin; however, in rare cases, diabetes may be monogenic. This is indeed the case in both Maturity Onset Diabetes of the Young (MODY) and neonatal diabetes. These disease subtypes are believed to be simpler than Type 1 (T1D) and Type 2 Diabetes (T2D), which allows for more precise modelling.