Publications by authors named "M M Grigg-Damberger"
Background And Objective: Evaluate relationships between PSG-confirmed OSA and SUDEP risk using the revised SUDEP Risk Inventory (rSUDEP-7).
Methods: Identified adults with epilepsy (AWE) who underwent PSG 2004-2016 at Cleveland Clinic. OSA was defined as apnea-hypopnea index (AHI)- ≥-5/h sleep; moderate/severe OSA as AHI≥15.
Article Synopsis
- Untreated obstructive sleep apnea (OSA) in acute ischemic stroke (AIS) patients increases health risks, making diagnosis and treatment difficult in this demographic.
- The study involved 27 AIS inpatients at Cleveland Clinic, where portable monitoring (PM) was used to identify OSA, and those with severe cases were offered therapy called auto-titrating positive airway pressure (APAP).
- Despite high ratings for ease of use of the PM device, only a small percentage of patients continued using the APAP treatment consistently, revealing significant barriers and the need for more research on better screening and treatment strategies for OSA in AIS patients.
A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in AD by years, and its presence has been shown to predict a faster disease course. In animal models of AD, amyloid and tau pathology are linked to cortical network hyperexcitability that precedes the first signs of memory decline.
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