Multi-Targeting Phytochemicals for Alzheimer's Disease.

Alzheimer's disease (AD) is a type of neurodegenerative illness in which β-amyloid (Aβ) and tau protein accumulate in neurons in the form of tangles. The pathophysiological pathway of AD consists of Aβ-amyloid peptides, tau proteins, and oxidative stress in neurons and increased neuro-inflammatory response. Food and Drug Administration in the United States has authorized various drugs for the effective treatment of AD, which include galantamine, rivastigmine, donepezil, memantine, sodium oligomannate, lecanemab, and aducanumab.

Predictors and Outcomes of Extubation Failure in Preterm Neonates: A Systematic Review.

Context: Extubation failure (EF) is common in preterm neonates and may be associated with adverse outcomes.

Objective: To systematically review and meta-analyze the existing literature on predictors and outcomes of EF in preterm neonates.

Data Sources: MEDLINE, Epub Ahead of Print, In-Process & Other Non-Indexed Citations, Embase (OvidSP), CINAHL (EBSCOHost), and Cochrane Library (Wiley) from 1995 onward.

Spatio-temporal analysis of extreme air pollution and risk assessment.

Extreme air pollution poses global health and environmental threats, necessitating robust policy interventions. This study first analyses the surface mass concentration of major aerosols (such as black carbon, organic carbon, dust, sea salts, and sulphates) to estimate global PM concentrations from 1980 to 2023. The developed model-estimated PM database was validated against data from 526 cities worldwide, showing strong accuracy, with RMSE, r, and R values of 7.

EMATA: a toolbox for the automatic extraction and modeling of arterial inputs for tracer kinetic analysis in [F]FDG brain studies.

Purpose: PET imaging is a pivotal tool for biomarker research aimed at personalized medicine. Leveraging the quantitative nature of PET requires knowledge of plasma radiotracer concentration. Typically, the arterial input function (AIF) is obtained through arterial cannulation, an invasive and technically demanding procedure.