Devil's staircase inside shrimp-shaped regions reveals periodicity of plateau spikes and bursts.

Slow-fast dynamics are intrinsically related to complex phenomena and are responsible for many of the homeostatic dynamics that keep biological systems healthy functioning. We study a discrete-time membrane potential model that can generate a diverse set of spiking behavior depending on the choice of slow-fast time scales, from fast spiking to bursting, or plateau action potentials-also known as cardiac spikes since they are characteristic in heart myocytes. The plateau of cardiac spikes can lose stability, generating early or delayed afterdepolarizations (EADs and DADs, respectively), both of which are related to cardiac arrhythmia.

Enhancing sickle cell leg ulcer healing with combined photodynamic and photobiomodulation therapies: A pilot experience.

Aim: This study aimed to evaluate the safety and efficacy of combined photodynamic therapy (PDT) and photobiomodulation (PBM) in treating sickle cell leg ulcers (SCLUs), with a focus on pain reduction and enhanced healing.

Materials And Methods: In this prospective, open-label, uncontrolled pilot study, ten SCD patients with 17 chronic leg ulcers received PDT and PBM treatments. Ulcer severity, pain levels, and microbiome changes were monitored, and clinical data were analyzed using appropriate statistical methods.

Nursing activities and quality of care: French perspectives and leadership challenges.

Objectives: to assess nurses' perceptions of nursing activities that contribute to quality of care in France.

Methods: descriptive cross-sectional study, between February and August 2020 in France. Sociodemographic characteristics were recorded, and nurses' perceptions were assessed using F-EPAECQC.

Forced intracellular degradation of xenoantigens as a modality for cell-based cancer immunotherapy.

Given recent leverage of mesenchymal stromal cells (MSCs) as a potent vaccination platform, we investigated whether forced degradation of an expressed experimental antigen fused to small degron sequences could prime potent antitumoral responses. Retrovirally gene-engineered MSCs were evaluated for their antigen presentation capacity, nature of generated peptide repertoire and therapeutic potency in syngeneic immunocompetent mice with pre-established solid T cell lymphoma. Despite lack of noticeable changes in gene expression, MSC-UBvR-OVA vaccination triggered potent T cell activation which can be attributable to the enriched cell surface presentation of OVA-derived peptides added to elevated mitochondrial reactive oxidative species (ROS) production, the latter being associated with efficient antigen processing.