Publications by authors named "M M Gladka"
Article Synopsis
- Intracellular calcium overload contributes to heart dysfunction, and understanding how to regulate calcium levels could help develop better heart failure therapies.
- The transcription factor ZEB2, induced by HIF1α in low-oxygen conditions, helps manage genes related to calcium handling and heart contraction, thus protecting against heart issues.
- ZEB2 enhances calcium uptake by increasing phosphorylation of phospholamban, while also reducing harmful signaling that leads to heart remodeling, making it a key player in maintaining heart function.
During mammalian heart development, the clustered genes encoding peptide hormones, Natriuretic Peptide A (; ANP) and B (; BNP), are transcriptionally co-regulated and co-expressed predominately in the atrial and ventricular trabecular cardiomyocytes. After birth, expression of and a natural antisense transcript becomes restricted to the atrial cardiomyocytes. Both and are induced by cardiac stress and serve as markers for cardiovascular dysfunction or injury.
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