Publications by authors named "M M Gallaher"
Background: There are limited data on clinical outcomes associated with the use of bebtelovimab for the treatment of coronavirus disease 2019 (COVID-19) among cancer patients. We aimed to define the clinical characteristics and outcomes among patients receiving bebtelovimab as part of the COVID-19 therapeutics program at our cancer center.
Methods: This is a retrospective cohort study of immunosuppressed adult patients who received bebtelovimab at Fred Hutchinson Cancer Center between March 2022, and November 2022.
Article Synopsis
- The study compares spinal injuries and movements between mid-size male and female subjects in reclined frontal car impacts, as previous research has overlooked sex differences in injury tolerance.
- Seven post-mortem human subjects (three females and four males) were tested in a simulated impact at 50 km/h, focusing on their spinal kinematics and the timing of vertebral fractures.
- Despite differences in pelvis geometry leading to adjustments in seating position for the females, both sexes exhibited similar spinal curvatures and kinematic responses, with comparable instances of L1 fractures occurring around the same time during the impact.
An estimated 20% of women suffer from a stress-related mood disorder including depression and anxiety during and after pregnancy, making these disorders among the most common complications of pregnancy. These stress-related disorders are associated with adverse pregnancy outcomes including gestational hypertension and preeclampsia, which are associated with poor cardiometabolic health postpartum. Despite these associations, the direct impact of stress and related disorders on maternal vascular health, and contributing mechanisms, remain understudied.
View Article and Find Full Text PDFA trial of positive airway pressure for the treatment of sleep apnea in pregnancy.
Am J Obstet Gynecol MFM
March 2023
Background: The pathophysiology of obstructive sleep apnea in pregnancy remains poorly understood and studies examining the effect of treatment with positive airway pressure on pregnancy have been limited.
Objective: This study aimed to perform a randomized controlled trial of positive airway pressure treatment for obstructive sleep apnea in pregnancy.
Study Design: Participants with a body mass index ≥30 kg/m underwent polysomnography at 14 to 20 weeks' gestation (visit 1) and those with obstructive sleep apnea (apnea-hypopnea index ≥5 but <50) were enrolled.
Study Objectives: To evaluate the impact of sleep-disordered breathing (SDB) on vascular, angiogenic and metabolic analytes in pregnancy.
Methods: Participants with a body mass index ≥30 kg/m underwent polysomnography at 14-20 weeks gestation (visit 1). Participants with SDB (defined as an apnea-hypopnea index ≥5 events/h) were then enrolled in a separate trial.