Formative research to address vaccine hesitancy in Tajikistan.

Introduction: Incomplete childhood vaccination is associated with caregiver vaccine hesitancy, conceptualized by "3 Cs": high complacency, low confidence, and low convenience. To expand on existing evidence drawn primarily from the Americas and Europe, and develop culturally appropriate interventions, this research explored drivers of vaccine hesitancy in the Central Asian country of Tajikistan.

Methods: In twelve diverse districts, clinic-based immunization record abstraction identified purposive samples of children who were up-to-date (N = 300) or not (N = 300) on all first year vaccines.

A mouse model of seizures in anti-N-methyl-d-aspartate receptor encephalitis.

Objective: Seizures develop in 80% of patients with anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, and these represent a major cause of morbidity and mortality. Anti-NMDAR antibodies have been linked to memory loss in encephalitis; however, their role in seizures has not been established. We determined whether anti-NMDAR antibodies from autoimmune encephalitis patients are pathogenic for seizures.

[The status of central and peripheral hemodynamics at different stages of combined peridural anesthesia with lidocaine and promedol in children].

The results of studies of central and peripheral hemodynamics during surgery performed under combined epidural anesthesia with lidocaine and promedol are presented. The study was performed on 82 children with surgical pathology aged 3 to 14 years. The state of hemodynamics was assessed using integral body plethysmography suggested by M.