Publications by authors named "M M G Leeflang"
Background: Sample collection is a key driver of accuracy in the diagnosis of SARS-CoV-2 infection. Viral load may vary at different anatomical sampling sites and accuracy may be compromised by difficulties obtaining specimens and the expertise of the person taking the sample. It is important to optimise sampling accuracy within cost, safety and accessibility constraints.
View Article and Find Full Text PDFBackground: Functional constipation is common in children and accurate diagnostic methods are essential for early diagnosis and effective management. The diagnostic accuracy of transabdominal ultrasound to diagnose functional constipation is unclear.
Objective: To evaluate the diagnostic accuracy of transverse rectal diameter measurement via transabdominal ultrasound in diagnosing children with functional constipation and in identifying fecal impaction.
Background: Guideline development on testing is known to be difficult for guideline developers. It requires consideration of various aspects, such as accuracy, purpose of testing, and consequences on management and people-important outcomes. This can be outlined in a test-management pathway.
View Article and Find Full Text PDFArticle Synopsis
- - The text discusses the importance of accurately diagnosing SARS-CoV-2 infections in managing the COVID-19 pandemic and highlights challenges faced due to shortages in RT-PCR testing reagents, prompting the search for alternative diagnostic methods.
- - The main goal is to evaluate the accuracy of alternative laboratory-based molecular tests for diagnosing SARS-CoV-2 infections, potentially enhancing testing capacity and resource utilization.
- - A systematic search for relevant studies was conducted, examining various diagnostic tests used for SARS-CoV-2, while ensuring comprehensive data collection and analysis to assess diagnostic effectiveness.