[Nutriome as the direction of the "main blow": determination of physiological needs in macro- and micronutrients, minor biologically active substances].

One of the essential parts of fundamental research in Nutrition Science is the determination of the physiological requirements of humans for energy and food substances. Research that has been carried out in this area over the past 90 years, consistently develops and improves the norms of physiological requirements for energy and nutrients for various groups of the population of the Russian Federation. In the 50 years of the last century in this research field, determining the values of daily intake for macronutrients (proteins, lipids and carbohydrates), was in the first place.

[THE CLINICAL COURSE OF HEPATITIS C IN CHILDREN WITH DIFFERENT VARIANTS OF THE GENE POLYMORPHISM IL28B].

Aim Of Investigation: The aim of the research is to study the clinical course of hepatitis C in children with different variants of the gene polymorphism of IL-28B.

Materials And Methods: We observed 94 children (46 girls and 48 boys) with chronic hepatitis C (CHC) in age from 3 to 17 years (mean age 10 years). There were significant differences in the distribution of allele frequencies in children with chronic hepatitis C and in the population.

[Modern trends of research in nutritiology and nutrition hygiene].

Advances in instrumental analysis and new knowledge in biology and medicine have allowed nutritiology and nutrition hygiene: 1) to go from studies of dietary intake of the population and the establishment of standards nutrient and energy needs to ensuring of public health and prevention of diseases by changing the composition and structure of nutrition; 2) to assume that the nutrition includes all the processes of cell and organism vital functions; 3) to develop an individualized nutrition and dietetics purposeful; 4) to evaluate energy value of ontogeny; 5) to ensure food safety at all stages of its manufacture; 6) to combine many disciplines into a single unit to achieve scientific and practical problems. Nutritiology achievements of the 21st century will be based on the development of cell biology as a basis for systematic studies of ontogenetic development of a unicellular or multicellular organism on the external factors, including food. OMICs-disciplines should be used for these purposes in order to understand the physiological meaning of transmission and coding signals to food interaction of genes, proteins, metabolites inside cells or in the organism, to reveal the mechanisms of encoding cell responses to these specific interactions.

Dynamics of locomotor activity and heat production in rats after acute stress.

The dynamics of locomotor activity and heat production were studied in rats demonstrating passive and active behavior in the open field test at different time after exposure to acute emotional stress caused by 12-h immobilization during dark hours. The most pronounced changes in behavior and heat production followed by disturbances in circadian rhythms of these parameters were detected within the first 2 days after stress. In contrast to behaviorally active rats, the most significant decrease in locomotor activity and heat production of passive animals subjected to emotional stress was observed during dark hours.

Proteomic study of rat hippocampus under conditions of emotional stress.

Proteomic differences in the hippocampus of stress-resistant and stress-sensitive rats were detected on the model of emotional stress. Differential expression of some proteins was detected in animals with different behavioral activity initially and after experimental stress exposure. Specific involvement of the hippocampus in the realization of stress response in animals with different sensitivity to emotional stress was demonstrated.