Publications by authors named "M M Frederick"
Article Synopsis
- Firefighters in California face a higher incidence of heat-related illness (HRI), with 2,185 claims recorded from 2001 to 2020, equating to 305.5 claims per 100,000 firefighters.
- Young firefighters aged 18 to 29 are significantly more at risk for HRI compared to older age groups, and the overall HRI rate has increased over the years, particularly between 2016 and 2020.
- Northern California counties, such as Shasta and Sacramento, exhibit the highest rates of HRI, highlighting the need for targeted prevention efforts due to rising temperatures and increasing wildfire occurrences.
Purpose: Exposomes are critical drivers of carcinogenesis. However, how they modulate tumor behavior remains unclear. Extensive clinical data link cigarette smoke as a key exposome that promotes aggressive tumors, higher rates of metastasis, reduced response to chemoradiotherapy, and suppressed anti-tumor immunity.
View Article and Find Full Text PDFUse of point-of-care ultrasound (POCUS) is integral to the practice of emergency medicine, and POCUS education is a required component of emergency medicine training. Developing POCUS skills requires iterative deliberate practice of image acquisition and interpretation. Providing feedback to learners regarding ultrasound image interpretation can be challenging for emergency medicine clinician educators.
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- Whole transcriptome sequencing (RNA-Seq) is a key method for studying cancer, but using RNA from frozen samples limits research possibilities due to the need for long-term patient follow-up.
- The study compared three RNA-Seq platforms using archival FFPE oropharyngeal squamous carcinoma specimens, establishing procedures for extracting DNA and RNA effectively from samples up to 20 years old.
- The results showed reliable RNA extraction, allowing the differentiation between HPV-associated and HPV-independent cancers, and confirmed patient ancestry through co-isolated DNA, emphasizing the reliability of the extraction methods developed.
Article Synopsis
- GIRK channels play a key role in inhibiting neuron activity in the hippocampus and are linked to cognitive issues in neurological disorders.
- Modifying GIRK channel activity in dorsal CA1 pyramidal neurons in mice affected their ability to recognize new objects, but didn't alter general activity levels or fear-based behaviors.
- The study reveals that GIRK channel strength impacts specific cognitive tasks, particularly in object recognition and the extinction of fear responses.