Publications by authors named "M M Ferrell"
The Dot/Icm type IVB secretion system (T4BSS) is a large, multisubunit complex that exports a vast array of substrates into eukaryotic host cells. DotO, a distant homolog of the T4ASS ATPase VirB4, associates with the bacterial inner membrane despite lacking hydrophobic transmembrane domains. Employing a genetic approach, we found DotO's membrane association is mediated by three inner-membrane Dot/Icm components, IcmT, and a combined DotJ-DotI complex (referred to as DotJI).
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- Spontaneous pancreatic portal vein fistula (PPVF) is a rare complication of pancreatic inflammation, often leading to bleeding and mortality; a systematic review analyzed the outcomes of this condition based on 52 relevant studies.
- The study included 74 patients (average age 53.5) with a significant history of alcohol use and chronic pancreatitis, highlighting abdominal pain as the most common symptom and computed tomography as the preferred diagnostic tool.
- While the overall rates of bleeding complications (17.6%) and mortality (16.2%) were relatively low, younger age was linked to a higher risk of bleeding, and older age along with polyarthritis were associated with increased mortality.
Colorectal cancer (CRC) is the third most common cancer in the United States. Recent epidemiological evidence demonstrates an increasing incidence of young-onset CRC cases, defined as CRC cases in individuals 50 years old or younger. Studies have established that alterations in both the WNT and TGF-Beta signaling pathways have contributed to CRC development.
View Article and Find Full Text PDFBackground And Aims: The pathways and metabolites that contribute to residual cardiovascular disease risks are unclear. Low-calorie sweeteners are widely used sugar substitutes in processed foods with presumed health benefits. Many low-calorie sweeteners are sugar alcohols that also are produced endogenously, albeit at levels over 1000-fold lower than observed following consumption as a sugar substitute.
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