Publications by authors named "M M Fattah"
Background: Norfloxacin (NFX) is a wide-spectrum antibacterial agent that suffers from low water solubility and first-pass metabolism. This diminishes its oral bioavailability by 60-70%.
Objective: This work aims to formulate a topical gel of NFX-loaded lipid polymer hybrid nanoparticles (NFX-LPHNPs) that combine the merits of liposomes and polymeric nanoparticles to overcome these problems.
Objectives: Do weekly prophylactic saline or acidic catheter washouts in addition to standard long-term catheter (LTC) care improve the outcomes of adults with LTC compared with standard LTC care only.
Design: Three-arm superiority open-label randomised controlled trial.
Setting: UK community-based study.
Organometal halide perovskite (OHP) composites are flexible and easy to synthesize, making them ideal for ambient mechanical energy harvesting. Yet, the output current density from the piezoelectric nanogenerators (PENGs) remains orders of magnitude lower than their ceramic counterparts. In prior composites, high permittivity nanoparticles enhance the dielectric constant (ϵ) but reduce the dielectric strength (E).
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- Recent research indicates that blocking the interaction between valosin-containing protein (VCP) and mutant huntingtin (mtHtt) can help prevent mitochondrial damage in Huntington's disease models.
- A newly developed protein-like polymer (PLP) has shown effectiveness in cellular and animal models, significantly inhibiting mitochondrial destruction and proving more stable than control oligopeptides.
- PLP has a remarkably longer circulation half-life (152 hours) and outperforms free peptide in efficacy tests, suggesting it could be a promising platform for developing treatments for central nervous system disorders.
Article Synopsis
- The study aimed to investigate how a high oral dose of omega-3 affects serum magnesium (Mg) and calcium (Ca) levels, and its impact on pain thresholds in patients.
- One hundred twenty patients were divided into two groups (omega-3 and placebo), and pain metrics were assessed before and after 8 weeks of treatment, along with serum analysis for Mg and Ca levels.
- Results showed significant improvements in pain scores for the omega-3 group, with negative correlations found between serum Ca and pain measures, indicating that increased Mg and Ca levels may help relieve fibromyalgia (FM) pain.