Publications by authors named "M M Epshteĭn"
Article Synopsis
- Current localized intravascular treatments usually involve solid implants or therapeutic injections, which can spread beyond the target area.* -
- This new technique uses fluids and their surface tension to specifically target and treat brain aneurysms by positioning a separate fluid phase at the aneurysm's neck.* -
- The method has been validated through computer simulations and experiments, showing successful localized delivery and treatment without affecting surrounding areas, making it a promising option for cardiovascular treatments.*
Neurological disorders pose a challenge for targeted therapy due to restricted access of therapeutic agents to the central nervous system (CNS). Current methods are limited by procedure-related risks, invasiveness, and insufficient CNS biodistribution. A novel percutaneous transvenous technology, currently in clinical trials for communicating hydrocephalus, offers a minimally invasive approach by providing endovascular access to the cerebrospinal fluid-filled cerebellopontine angle (CPA) cistern.
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- * In a controlled experiment, ten dogs underwent a procedure to block blood flow to the brain temporarily and were divided into two groups: one receiving selective brain cooling and the other receiving no treatment.
- * Results indicated that while overall survival rates were similar, the cooled group experienced significantly slower progression of brain tissue damage after blood flow restoration compared to the control group.
X-ray attenuating contrast agents for imaging thrombi directly during endovascular thrombectomy (EVT) are urgently needed for shortening the wait time for treatment and for reducing the chances of blood clot fragmentation. Neutrophil extracellular traps (NETs) are a product of an innate immune system response by which neutrophils release decondensed chromatin strands decorated with granule and cytosolic proteins, including neutrophil elastase and citrullinated histone H3 (CitH3). NETs are frequently found within fibrous thrombi in pathology and represent a promising target for thrombi-specific imaging agents due to their common occurrence in human cerebrovascular thrombi.
View Article and Find Full Text PDFDynamic perviousness is a novel imaging biomarker, with clot density measurements at multiple timepoints to allow longer contrast to thrombus interaction. We investigated the correlations between dynamic perviousness and clot composition in the setting of acute ischemic stroke. Thirty-nine patients with large vessel occlusion (LVO) undergoing mechanical thrombectomy (MT) were analyzed.
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