Influence of sintering temperature and aging on the color and translucency of zirconia.

Statement Of Problem: Translucent zirconias are promising materials for monolithic prostheses. However, information on their optical behavior after sintering and aging protocols is scarce.

Purpose: The purpose of this in vitro study was to evaluate the color and translucency of zirconia subjected to different sintering temperatures and aging.

Speech recognition and real-ear-measured amplification in hearing-aid users with various grades of hearing loss.

Objective: The relationship between aided speech recognition and hearing-aid (HA) amplification was investigated in a retrospective study.

Design And Study Sample: Pure-tone thresholds, aided and unaided speech recognition and real-ear measurements of 635 ears in 374 HA users were reviewed. Ears were classified according to pure-tone average (PTA) and real-ear aided response (REAR) in relation to the targets of NAL-NL2 and DSL v5.

Illness perceptions in cochlear implant users - a longitudinal study.

Purpose: 'Illness perceptions' refers to the thoughts and ideas a person has about an illness. According to Leventhal's Self-Regulatory Model (SRM), changing the threatening illness perceptions of cochlear implant (CI) recipients can be a further step in optimizing hearing outcomes with the CI. The aims of the present study were to assess users' illness perceptions and to determine whether perceptions change during six months of CI rehabilitation.

Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome.

Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset hypertrophic cardiomyopathy. In this study, we investigate the mechanistic consequences of a homozygous variant LZTR1 by using patient-specific and CRISPR-Cas9-corrected induced pluripotent stem cell (iPSC) cardiomyocytes. Molecular, cellular, and functional phenotyping in combination with in silico prediction identify an LZTR1-specific disease mechanism provoking cardiac hypertrophy.