Publications by authors named "M M Ehrhardt"
Purpose: The Healthy Hearts pilot study evaluated the effect of an eHealth motivational interviewing-framed intervention on cardiomyopathy screening-related knowledge, health beliefs, intrinsic motivation, and behavioral action steps among adult survivors of childhood cancer.
Methods: We consented N = 73 survivors to participate in a single-arm pilot study. Participants completed an online baseline survey (n = 68) assessing knowledge, health beliefs, and intrinsic motivation related to cancer therapy-induced cardiomyopathy and screening echocardiograms.
Background: The relationships among treatment exposures, body composition, and estimated glomerular filtration rate (eGFR) in adult survivors of Wilms tumor have not been well studied.
Methods: We evaluated body composition with dual-energy x-ray absorptiometry (DXA) and eGFR with the updated Chronic Kidney Disease Epidemiology Collaboration equations (creatinine only-eGFR, cystatin C only-eGFR, creatinine and cystatin C-eGFR) without race in 134 adults previously treated for unilateral, non-syndromic Wilms tumor at St. Jude Children's Research Hospital between 1964 and 2004 with chemotherapy and with (hemiabdomen [HA] or whole abdomen [WA]) or without radiation therapy (RT).
In this work, we propose a new primal-dual algorithm with adaptive step sizes. The stochastic primal-dual hybrid gradient (SPDHG) algorithm with constant step sizes has become widely applied in large-scale convex optimization across many scientific fields due to its scalability. While the product of the primal and dual step sizes is subject to an upper-bound in order to ensure convergence, the selection of the ratio of the step sizes is critical in applications.
View Article and Find Full Text PDFNatural killer (NK) cell tumor infiltration is associated with good prognosis in patients with metastatic castration-resistant prostate cancer (mCRPC). NK cells recognize and kill targets by a process called natural cytotoxicity. We hypothesized that promoting an antigen-specific synapse with co-activation may enhance NK cell function in mCRPC.
View Article and Find Full Text PDFArticle Synopsis
- Ataxia telangiectasia (A-T) is a genetic disorder that affects DNA repair and increases the risk of developing cancers, with 16.5% of affected individuals diagnosed with primary cancers in a study.
- The analysis revealed that the cumulative incidence of cancer reached 29% by age 35, with non-Hodgkin lymphoma being the most common hematologic cancer, while solid tumors were more prevalent in individuals aged 18 and over.
- The study found that standard chemotherapy led to a higher risk of death and significant treatment-related toxicities, emphasizing the necessity for more effective and safer treatment options for individuals with A-T.