Publications by authors named "M M Dodonov"
The role of pulsatile (PP) versus non-pulsatile (NP) flow during a cardiopulmonary bypass (CPB) is still debated. This study's aim was to analyze hemodynamic effects, endothelial reactivity and erythrocytes response during a CPB with PP or NP. Fifty-two patients undergoing an aortic valve replacement were prospectively randomized for surgery with either PP or NP flow.
View Article and Find Full Text PDFValve-in-valve transcatheter aortic valve replacement (ViV-TAVR) has been popularized as an attractive alternative to redo surgical aortic valve replacement for bioprosthetic valve dysfunction. Acute valve thrombosis has been occasionally described after ViV-TAVR. Lack of anticoagulant therapy has been always considered a crucial risk factor.
View Article and Find Full Text PDFArticle Synopsis
- The study focused on the OPG/RANK/RANKL signaling pathway in patients with calcific aortic valve disease (CAVD) to see how it affects mineralization markers in their blood.
- The researchers found that CAVD patients had significantly higher levels of OPG in their blood and increased RANKL expression in their peripheral blood mononuclear cells (PBMC).
- They concluded that higher RANKL levels are linked to more valve calcification and promote mineralization in valve interstitial cells (VIC) in laboratory experiments.
Purpose: Cardiopulmonary bypass is still a major cause of lung injury and delay in pulmonary recovery after cardiac surgery. Although it has been shown that pulsatile flow induced by intra-aortic balloon pumping is beneficial for preserving lung function, it is not clear if the same beneficial effect can be accomplished with pulsatile flow generated in the extracorporeal circuit. Therefore, we investigated the effect of pulsatile flow, produced by a centrifugal pump, on lung function in elderly patients.
View Article and Find Full Text PDFObjectives: To evaluate if pulsatile cardiopulmonary bypass (CPB) has any protective influence on renal function in elderly patients undergoing aortic valve replacement (AVR).
Methods: Forty-six patients (≥ 75 years old) with aortic valve stenosis underwent AVR with either pulsatile perfusion (PP) or non-pulsatile perfusion (NP) during CPB. Haemodynamic efficacy of the blood pump during either type of perfusion was described in terms of the energy equivalent pressure and the surplus haemodynamic energy.