Publications by authors named "M M Diaby"
Article Synopsis
- The study investigated the effectiveness and safety of the rVSV-ZEBOV vaccine against Zaire Ebolavirus disease among contacts of EVD survivors, focusing on the influence of pre-existing immunity on vaccination outcomes.
- Ten percent of participants had pre-existing antibodies, but both those with and without antibodies showed significant increases in IgG levels post-vaccination, indicating strong immune responses.
- The findings support the vaccine's safety and suggest that pre-vaccination antibody screening is unnecessary, as it does not negatively impact the immune response to the vaccine.
Article Synopsis
- - The study examines the prevalence of arboviruses in sub-Saharan Africa, highlighting their ongoing public health threat and the importance of seroprevalence surveys for informing interventions in the absence of vaccines and treatments.
- - A comprehensive analysis reviewed 165 studies involving over 186,000 participants across 27 countries from 2000 to 2022, revealing varied seroprevalence rates for several arboviruses, with Chikungunya and dengue showing the highest rates at 23.7% and 22.7%, respectively.
- - The findings indicate considerable differences in seroprevalence based on factors like country, population demographics, age groups, and laboratory techniques, emphasizing the need for tailored public
Objectives: This study aimed to investigate the prevalence of orthoebolavirus antibodies in Madina Oula, a non-epidemic rural area in Guinea, in 2022.
Methods: A cross-sectional study was conducted from March 14 to April 3, 2022 involving recording household and socio-demographic characteristics, lifestyle data, and collecting dried blood spots from 878 individuals in 235 households. Dried blood spots were tested using multiplex serology to detect antibodies to different orthoebolaviruses: Ebola virus, Bundibugyo virus, Sudan virus, Reston virus, and Bombali virus.
Novel active DNA transposons, such as Spy transposons from the PHIS superfamily, are identified through bioinformatics in this study. The native transposases cgSpy and cvSpy displayed transposition activities of approximately 85% and 35% compared to the hyperactive piggyBac transposase (hyPB). The cgSpy transposon showed unique characteristics, including a lack of overproduction inhibition and reduced efficiency for insertion sizes between 3.
View Article and Find Full Text PDFApoptotic mechanism of development inhibition in zebrafish induced by esketamine.
Toxicol Appl Pharmacol
January 2024
Esketamine, a widely used intravenous general anesthetic, is also employed for obstetric and pediatric anesthesia, and depression treatment. However, concerns regarding esketamine abuse have emerged. Moreover, the potential in vivo toxicity of esketamine on growth and development remains unclear.
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